Causes of obstructive uropathy Obstructive uropathy can occur due to a variety of factors. Compression can lead to damage to your kidneys and ureters. Temporary or permanent blockages in your ureter or urethra, through which urine exits your body, can result from: Injuries such as a pelvic fracture Tumor mass that spreads to your kidneys, bladder, uterus, or colon Diseases of the digestive tract Kidney stones trapped in your ureter Blood clots